Liver and intrahepatic bile ducts - tumor - Benign cystic mesothelioma

Home Chapter Home Jobs Conferences Fellowships Books

Liver and intrahepatic bile ducts - tumor

Benign tumors/conditions

Benign cystic mesothelioma

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

See similar topic in Small bowel chapter

General
=========================================================================

● Very rare in liver; considered reactive due to its association with abdominal surgery and endometriosis
● Also called multilocular peritoneal inclusion cyst, multifocal peritoneal inclusion cyst, benign muticystic peritoneal mesothelioma
● Arises from undifferentiated mesothelial or submesothelial cells over liver capsule (Arch Pathol Lab Med 2001;125:944)
● Female predominance, may be due to hormonal changes (Am J Surg Pathol 2002;26:1523)
● Laboratory: elevated CA 19-9 in serum and cyst fluid

Treatment
=========================================================================

● Excision; indolent, slowly progressive and curable, but may recur

Case reports
=========================================================================

● 51 year old woman (Am J Surg Pathol 2002;26:1523)
● 58 year old man with elevated CA 19-9, multiple benign appearing liver cysts and single cysts in kidney and pancreas (Arch Pathol Lab Med 2001;125:944)

Gross description
=========================================================================

● Partially cystic, encapsulated mass with soft-glistening surface

Gross images
=========================================================================

Cyst before and after aspiration

Micro description
=========================================================================

● Well-encapsulated, partially cystic and highly vascular; no cirrhosis
● Loose cords of tumor cells separated by medium to large vessels with walls of varying thickness
● Cystic spaces lined by tumor cells, either epithelioid or with hobnail appearance

Micro images
=========================================================================

Various images and immunostains

Positive stains
=========================================================================

● CK8/18 (CAM 5.2), calretinin, EMA, vimentin and estrogen receptor

Electron microscopy description
=========================================================================

● Desmosomes and microvilli

Differential diagnosis
=========================================================================

● Biliary cystadenoma
● Congenital mesothelial cyst: usually neonates (Pediatr Surg Int 2008;24:463)
● Cystic neoplasms
● Hydatid cyst
● Serous cystadenoma
● Vascular neoplasms (due to high vascularity)

End of Liver and intrahepatic bile ducts - tumor > Benign tumors/conditions > Benign cystic mesothelioma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).