Liver and intrahepatic bile ducts - tumor
Benign tumors / conditions
Benign cystic mesothelioma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 14 November 2017, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Benign cystic mesothelioma liver

See also: Small bowel chapter
Cite this page: Jain, D. Benign cystic mesothelioma. website. Accessed October 16th, 2018.
Definition / general
  • Very rare in liver; considered reactive due to its association with abdominal surgery and endometriosis
  • Also called multilocular peritoneal inclusion cyst, multifocal peritoneal inclusion cyst, benign muticystic peritoneal mesothelioma
  • Arises from undifferentiated mesothelial or submesothelial cells over liver capsule (Arch Pathol Lab Med 2001;125:944)
  • Female predominance, may be due to hormonal changes (Am J Surg Pathol 2002;26:1523)
  • Elevated CA 19-9 in serum and cyst fluid
Case reports
  • Excision; indolent, slowly progressive and curable but may recur
Clinical images

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Cyst before and after aspiration

Gross description
  • Partially cystic, encapsulated mass with soft glistening surface
Microscopic (histologic) description
  • Well encapsulated, partially cystic and highly vascular; no cirrhosis
  • Loose cords of tumor cells separated by medium to large vessels with walls of varying thickness
  • Cystic spaces lined by tumor cells, either epithelioid or with hobnail appearance
Microscopic (histologic) images

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Various images and immunostains

Positive stains
Electron microscopy description
  • Desmosomes and microvilli
Differential diagnosis