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Liver and intrahepatic bile ducts - tumor

Other malignancies

Carcinoid tumor

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.


● Well-differentiated neuroendocrine tumor
● Very rare as primary hepatic tumor (<100 cases reported); usually represents metastasis from GI tumor (small intestinal primaries may be very small)
● Slightly more frequent in females
● Rarely associated with Zollinger-Ellison syndrome, VIP production
● Indolent low-grade clinical course with prolonged survival, but recurs or metastasizes more frequently than appendiceal carcinoids (Arch Pathol Lab Med 2003;127:1200)

Case reports

● 51 year old man with Zollinger Ellison syndrome (Cases J 2009;2:6346)
● 62 year old woman (World J Surg Oncol 2008;6:91)


● Surgical resection

Gross images

62 year old woman with tan gray tumor that has soft, fish-flesh cut surface

Micro description

● Nested, trabecular or microacinar architecture
● Composed of small, uniform tumor cells with granular chromatin and round nuclei
● Often stromal hyalinization

Micro images

62 year old woman with primary hepatic carcinoid tumor

Primary liver tumor in patient with ZE syndrome

Liver metastases from colon primary

A/B: liver metastases from lung primary

End of Liver and intrahepatic bile ducts - tumor > Other malignancies > Carcinoid tumor

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