Liver and intrahepatic bile ducts - tumor
Other malignancies

Author: Deepali Jain, M.D. (see Authors page)

Revised: 30 November 2017, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Carcinosarcoma[TI] liver[TI]

Cite this page: Jain, D. Carcinosarcoma. website. Accessed October 15th, 2018.
Definition / general
  • Malignant tumor containing intimate mixture of carcinomatous (either hepatocellular carcinoma or cholangiocellular carcinoma) and sarcomatous elements; sarcomatous component may be chondrosarcomatous, fibrosarcoma, leiomyosarcomatous, osteosarcoma, rhabdomyosarcoma, undifferentiated (IARC: 8980 / 3 Carcinosarcoma, NOS [Accessed 30 November 2017])
  • Also called "malignant mixed tumor"
  • Predominantly older men
  • Risk factors similar to HCC, including cirrhosis, hepatitis B infection
  • Very poor prognosis due to sarcomatous component (Am J Surg Pathol 2007;31:817)
Case reports
Gross images

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Gray white tumor with necrosis

Microscopic (histologic) images

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Tubular structures and chondrosarcoma

Various images