Liver and intrahepatic bile ducts - tumor
Benign tumors / conditions
Castleman disease

Topic Completed: 1 February 2012

Revised: 24 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Castleman disease liver

Deepali Jain, M.D.
Page views in 2018: 268
Page views in 2019 to date: 284
Cite this page: Jain D. Castleman disease. website. Accessed December 13th, 2019.
Definition / general
  • Uncommon lymphoproliferative disorder involving lymph nodes in one region or systemic
  • Also called angiofollicular hyperplasia
Microscopic (histologic) description
  • Stellate fibrous scar separates small nodules of disorganized large and clear hepatocytes
  • Scar contains hyperplastic follicles with germinal centers, separated by sheets of plasma cells and vessels
  • Small lymphocytes are arranged in onion skin pattern around follicles
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