Liver and intrahepatic bile ducts - tumor

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Liver and intrahepatic bile ducts - tumor

Other malignancies

Germ cell tumors

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● < 1% of all liver neoplasms, mostly children < 3 years old, 50% are malignant
● Usually teratoma, choriocarcinoma, yolk sac tumor
● Teratoma: uncommon, usually girls < 1 year old

Case reports
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● 3 year old boy with primary hepatic mixed germ cell tumor (Acta Oncol 2007;46:1198)
● 3 year old boy with mixed hepatoblastoma and teratoma of liver (Diagn Pathol 2009;4:37)
● 34 year old man with primary mixed germ cell tumor with sarcomatous component (World J Gastroenterol 2010;16:652)

Gross description
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● Large, cystic, calcified

Gross images
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Teratoma

Micro description
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● Teratomas: derivatives of all 3 cell layers; often cystic, lined by ectoderm with skin appendages or endoderm; rarely have neuroendocrine differentiation (Histopathology 2003;43:306)
● May have other liver tumor component (hepatoblastoma)

Micro images
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Primary mixed germ cell tumor (yolk sac tumor and immature teratoma)

Primary mixed germ cell tumor (yolk sac tumor and embryonal carcinoma)

Teratoma

Molecular images
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Primary mixed germ cell tumor (yolk sac tumor and immature teratoma)

Differential diagnosis
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● Hepatoblastoma
● Metastatic disease: see Nihon Kokyuki Gakkai Zasshi 2007;45:318

End of Liver and intrahepatic bile ducts - tumor > Other malignancies > Germ cell tumors

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