Liver and intrahepatic bile ducts - tumor
Leukemia / lymphoma
Hepatosplenic alpha beta T cell lymphoma

Topic Completed: 1 February 2012

Revised: 28 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Hepatosplenic T cell lymphoma alpha beta

Deepali Jain, M.D.
Page views in 2018: 110
Page views in 2019 to date: 120
Cite this page: Jain D. Hepatosplenic alpha beta T cell lymphoma. website. Accessed November 19th, 2019.
Definition / general
  • May be clinical variant of gamma delta T cell lymphoma but less common (Am J Surg Pathol 2001;25:285)
  • Associated with thrombocytopenia, anemia, hepatosplenomegaly, B symptoms but usually no lymphadenopathy
  • Mean age 36 years old but wide range; female preponderance
  • Aggressive clinical course leading to death
Case reports
Microscopic (histologic) description
  • Sinusoidal lymphoid infiltrate within liver, splenic red pulp and bone marrow of small / medium sized atypical lymphoid cells with scant / moderate cytoplasm, round / oval nuclei, slightly dispersed chromatin and indistinct nucleoli
  • Marked periportal infiltrates in CD57+ cases
Microscopic (histologic) images

Images hosted on other servers:

H&E, CD45RO and S100

Positive stains
Negative stains
Molecular / cytogenetics description
  • Isochromosome 7q
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