Liver and intrahepatic bile ducts - tumor
Leukemia / lymphoma
Hepatosplenic gamma delta T cell lymphoma




Topic Completed: 1 February 2012

Revised: 28 January 2019, last major update February 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Hepatosplenic gamma delta T cell lymphoma[TIAB]

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Cite this page: Jain D. Hepatosplenic gamma delta T cell lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/livertumorhepatosplenicgammadelta.html. Accessed March 19th, 2019.
Definition / general
  • Rare, < 100 cases reported
  • Usually young or middle aged men with massive hepatosplenomegaly and elevated liver function tests, B symptoms (fever, night sweats, weight loss) but no significant nodal involvement, pancytopenia, aggressive clinical course (median survival 8 months)
  • Refractory to chemotherapy
  • Often occurs after solid organ transplantation but reduction in immunosuppression does not affect clinical course in Crohn's disease patients
Case reports
  • 45 year old man with leukemic disease 5 years after renal transplant and continuous immunosuppression with cyclosporine A and prednisolone (Hum Pathol 2002;33:253)
Microscopic (histologic) description
  • Sinusoidal lymphoid infiltrate of liver (3+ lymphocytes fill / expand sinusoid), spleen and bone marrow by medium sized lymphocytes with condensed chromatin and rim of eosinophilic cytoplasm
Positive stains
Negative stains
Molecular / cytogenetics description
  • Isochromosome 7q (i7q10 in 2/3), trisomy 8 and Y-
Differential diagnosis
  • CMV and EBV have sinusoidal infiltrate but less bulky portal inflammation, hepatocyte ballooning, lobular disarray, higher levels of transaminases
  • Drug related hepatitis
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