Liver and intrahepatic bile ducts - tumor
Leukemia / lymphoma
Hodgkin lymphoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 19 January 2017, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Hodgkin lymphoma[TI] liver[TIAB]

Cite this page: Jain, D. Hodgkin lymphoma. website. Accessed May 23rd, 2018.
Definition / general
  • Liver involvement found in 55% of Hodgkin patients at autopsy and 5 - 10% at liver biopsy
  • Rare in classical Hodgkin lymphoma unless extensive involvement of lymph nodes and spleen; most common in lymphocyte depleted and mixed cellularity subtypes
Gross description
  • Either diffuse miliary nodules or bulky, tan white masses
Microscopic (histologic) description
  • Atypical mononuclear cells with prominent nucleoli present in portal tracts; background of polymorphous inflammatory infiltrate
  • Epithelioid cell granulomas in 8 - 12%
  • May see vanishing bile duct syndrome with ductule proliferation
  • Reed-Sternberg cells are rare
  • Granulomatous hepatitis may precede clinical expression of Hodgkin lymphoma
Microscopic (histologic) images

Images hosted on PathOut server, COW #447, contributed by Dr. Mariam A. Molani:

Hodgkin lymphoma, mixed cellularity subtype

Images hosted on other servers:

Numerous eosinophils and rare Reed-Sternberg cells

CD30+ Reed-Sternberg cells

Positive stains