Liver and intrahepatic bile ducts - tumor

Home Chapter Home Jobs Conferences Fellowships Books

Liver and intrahepatic bile ducts - tumor

Leukemia / lymphoma

Hodgkin lymphoma

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Liver involvement found in 55% of Hodgkin patients at autopsy and 5-10% at liver biopsy
● Rare in classical Hodgkin lymphoma unless extensive involvement of lymph nodes and spleen; most common in lymphocyte depleted and mixed cellularity subtypes

Gross description
=========================================================================

● Either diffuse miliary nodules or bulky, tan-white masses

Micro description
=========================================================================

● Atypical mononuclear cells with prominent nucleoli present in portal tracts; background of polymorphous inflammatory infiltrate
● Epithelioid cell granulomas in 8–12%
● May see vanishing bile duct syndrome with ductule proliferation
● Reed-Sternberg cells are rare
● Granulomatous hepatitis may precede clinical expression of Hodgkin lymphoma

Micro images
=========================================================================

Left: numerous eosinophils and rare Reed-Sternberg cells; right: CD30+ R-S cells

Positive stains
=========================================================================

● CD15, CD30, PAX5, OCT2 , BOB1

Differential diagnosis
=========================================================================

● Abscess
● Inflammatory myofibroblastic tumor
● Dendritic cell tumor: CD21+, CD35+

End of Liver and intrahepatic bile ducts - tumor > Leukemia / lymphoma > Hodgkin’s lymphoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).