Liver and intrahepatic bile ducts - tumor
Leukemia / lymphoma
Hodgkin lymphoma

Topic Completed: 1 February 2012

Revised: 28 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Hodgkin lymphoma[TI] liver[TIAB]

Deepali Jain, M.D.
Page views in 2018: 375
Page views in 2019 to date: 533
Cite this page: Jain D. Hodgkin lymphoma. website. Accessed December 10th, 2019.
Definition / general
  • Liver involvement found in 55% of Hodgkin patients at autopsy and 5 - 10% at liver biopsy
  • Rare in classical Hodgkin lymphoma unless extensive involvement of lymph nodes and spleen; most common in lymphocyte depleted and mixed cellularity subtypes
Gross description
  • Either diffuse miliary nodules or bulky, tan white masses
Microscopic (histologic) description
  • Atypical mononuclear cells with prominent nucleoli present in portal tracts; background of polymorphous inflammatory infiltrate
  • Epithelioid cell granulomas in 8 - 12%
  • May see vanishing bile duct syndrome with ductule proliferation
  • Reed-Sternberg cells are rare
  • Granulomatous hepatitis may precede clinical expression of Hodgkin lymphoma
Microscopic (histologic) images

Images hosted on PathOut server, COW #447, contributed by Dr. Mariam A. Molani:

Hodgkin lymphoma, mixed cellularity subtype

Images hosted on other servers:

Numerous eosinophils and rare Reed-Sternberg cells

CD30+ Reed-Sternberg cells

Positive stains
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