Liver and intrahepatic bile ducts - tumor
Leukemia / lymphoma
Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.
● Liver involvement found in 55% of Hodgkin patients at autopsy and 5-10% at liver biopsy
● Rare in classical Hodgkin lymphoma unless extensive involvement of lymph nodes and spleen; most common in lymphocyte depleted and mixed cellularity subtypes
● Either diffuse miliary nodules or bulky, tan-white masses
● Atypical mononuclear cells with prominent nucleoli present in portal tracts; background of polymorphous inflammatory infiltrate
● Epithelioid cell granulomas in 8–12%
● May see vanishing bile duct syndrome with ductule proliferation
● Reed-Sternberg cells are rare
● Granulomatous hepatitis may precede clinical expression of Hodgkin lymphoma
Left: numerous eosinophils and rare Reed-Sternberg cells; right: CD30+ R-S cells
● CD15, CD30, PAX5, OCT2 , BOB1
● Inflammatory myofibroblastic tumor
● Dendritic cell tumor: CD21+, CD35+
End of Liver and intrahepatic bile ducts - tumor > Leukemia / lymphoma > Hodgkin’s lymphoma
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