Liver and intrahepatic bile ducts - tumor

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Liver and intrahepatic bile ducts - tumor

Benign tumors / conditions

Juvenile xanthogranuloma

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● Non-Langerhans cell histiocytic disorder, usually through age 19 years
● Usually solitary cutaneous lesion, but rarely involves liver, may cause hepatic failure, may regress (Am J Surg Pathol 2003;27:579)

Micro description
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● Predominantly portal infiltrate spilling over into the adjacent lobule, but sparing the biliary tree
● Spindle cells mixed with mononuclear cells or forming short fascicles
● Diffuse giant cell transformation; may have Touton giant cells

Positive stains
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● Vimentin, CD68 and factor XIIIa

Negative stains
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● S100, CD1a

End of Liver and intrahepatic bile ducts - tumor > Benign tumors / conditions > Juvenile xanthogranuloma

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