Liver and intrahepatic bile ducts - tumor
Benign tumors / conditions

Topic Completed: 1 February 2012

Revised: 25 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Leiomyoma[TI] liver[TIAB]

Deepali Jain, M.D.
Page views in 2019: 181
Page views in 2020 to date: 37
Cite this page: Jain D. Leiomyoma. website. Accessed April 3rd, 2020.
Definition / general
  • Solitary nodule resembling leiomyoma elsewhere; may resemble metastatic well differentiated leiomyosarcoma
Clinical features
  • For diagnosis, should be no primary leiomyomas elsewhere in body
  • Arises from mesenchymal tissue of the liver - smooth muscle cells of vessels or biliary tree
  • Higher prevalence in patients with immunosuppression or organ transplantation (HIV or EBV infection)
  • Metastasis and recurrence may develop in histologically benign leiomyomas
Microscopic (histologic) description
  • Spindle cell proliferation with elongated nuclei, eosinophilic cytoplasm; may have abundant T cells
  • No nuclear atypia, hemorrhage or necrosis
  • Criteria for malignancy: increased mitotic rate (> 1/10 high power fields), cellular atypia with nuclear pleomorphism, dense cellularity and degenerative changes
Differential diagnosis
  • GIST: cells don't resemble smooth muscle, CD117+
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