Liver and intrahepatic bile ducts - tumor
Benign tumors / conditions

Author: Deepali Jain, M.D. (see Authors page)

Revised: 16 November 2017, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Leiomyoma[TI] liver[TIAB]

Cite this page: Jain, D. Leiomyoma. website. Accessed October 16th, 2018.
Definition / general
  • Solitary nodule resembling leiomyoma elsewhere; may resemble metastatic well differentiated leiomyosarcoma
Clinical features
  • For diagnosis, should be no primary leiomyomas elsewhere in body
  • Arises from mesenchymal tissue of the liver - smooth muscle cells of vessels or biliary tree
  • Higher prevalence in patients with immunosuppression or organ transplantation (HIV or EBV infection)
  • Metastasis and recurrence may develop in histologically benign leiomyomas
Microscopic (histologic) description
  • Spindle cell proliferation with elongated nuclei, eosinophilic cytoplasm; may have abundant T cells
  • No nuclear atypia, hemorrhage or necrosis
  • Criteria for malignancy: increased mitotic rate (> 1/10 high power fields), cellular atypia with nuclear pleomorphism, dense cellularity and degenerative changes
Differential diagnosis
  • GIST: cells don't resemble smooth muscle, CD117+