Liver and intrahepatic bile ducts - tumor
Leukemia / lymphoma

Topic Completed: 1 February 2012

Revised: 28 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Leukemia[TI] liver[TI] free full text[sb]

Deepali Jain, M.D.
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Cite this page: Jain D. Leukemia. website. Accessed September 22nd, 2019.
Gross description
  • Usually hepatomegaly but no discrete nodules except for SLL / CLL
  • Lymphoblastic lymphoma only rarely presents in liver with no involvement of blood or marrow
Acute T / B cell leukemia / lymphoma
Microscopic (histologic) description
  • Pleomorphic lymphocytes, sinusoidal pattern of infiltration with less hepatocellular injury
Acute myeloid leukemia
Case reports

Microscopic (histologic) images

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Erythroleukemic blasts

Positive stains
Chronic lymphoblastic leukemia
Definition / general
  • Liver involvement common

Microscopic (histologic) description
  • Periportal infiltrate of monomorphic small lymphocytes with minimal cytoplasm
Chronic myelogenous leukemia
Definition / general
  • Liver involvement common (50%)

Microscopic (histologic) description
  • Sinusoidal infiltrate of various myeloid precursors
  • Resembles surgical hepatitis (margination reaction of neutrophils in liver sinusoids related to prolonged surgery)
Hairy cell leukemia
Definition / general
  • Hepatomegaly in up to 1/3
  • Associated with pancytopenia

Microscopic (histologic) description
  • Portal and sinusoidal infiltration, clear cytoplasm, round / reniform nuclei, appears as "beads on a string" along sinusoids; may have angiomatous spaces (World J Gastroenterol 2009;15:4453)

Positive stains
Large granular lymphocyte leukemia
Definition / general
  • Associated with leukemia and neutropenia
  • Peripheral smear shows large granular lymphocytes

Microscopic (histologic) description
  • Round lymphocytes with abundant pale cytoplasm
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