Liver and intrahepatic bile ducts - tumor

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Liver and intrahepatic bile ducts - tumor

Other malignancies

Liposarcoma

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● Rare, < 10 cases reported
● Develops in non-cirrhotic liver
● Contraindication for liver transplantation

Case reports
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● 54 year old woman with myxoid liposarcoma (Arch Pathol Lab Med 2001;125:410)

Gross description
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● Large tumor with yellow-tan, fleshy mass, focal hemorrhage and necrosis as well as satellite tumor nodules
● Non-cirrhotic remaining liver

Gross images
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Metastatic tumor from leg primary

Micro description
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● Myxoid: myxoid stroma with plexiform vessels; numerous lipoblasts with granular cytoplasm, nuclei indented by fat vacuoles; some spindled cells, some anaplastic cells

Micro images
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Myxoid liposarcoma and lipoblasts

Various images

Metastatic tumor from leg primary has extensive round cell component

Positive stains
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● Vimentin, alpha smooth muscle actin (focal)

Negative stains
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● S100, keratin, HMB45, CD34

Electron microscopy images
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Intracellular lipid indents nucleus

End of Liver and intrahepatic bile ducts - tumor > Other malignancies > Liposarcoma

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