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Liver and intrahepatic bile ducts - Tumor

Dysplasia

Liver cell dysplasia


Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● By definition, dysplastic foci measure <1 mm in diameter, detected in livers on microscopic exam incidentally in biopsies or resected specimens with or without cirrhosis and are often multiple
● Apparent precursor lesion of hepatocellular carcinoma
● Iron free foci in genetic hemochromatosis (resistance to hemosiderin accumulation) are proliferative lesions associated with a high incidence of hepatocellular carcinoma (Hepatology 1993;18:1363)

Micro description
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● Large cells with abundant cytoplasm and relatively normal nuclear/cytoplasmic ratio (large cell change) or small cells with minimal basophilic cytoplasm and increased N/C ratio (small cell change)
● Both have enlarged, pleomorphic nuclei, clumped chromatin, thick nuclear membranes, prominent nucleoli
● Large cell change may be dysplastic or reactive (Hepatol 2006;45:734)
● Small cell change may represent a more “advanced” lesion than large cell change (Hepatology 2007;45:968)

End of Liver and intrahepatic bile ducts - Tumor > Dysplasia > Liver cell dysplasia


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