Liver and intrahepatic bile ducts

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Liver and intrahepatic bile ducts - Tumor

Benign tumors

Lymphangioma

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● Very rare - <25 cases reported (Hepatol Int 2010;4:784, Surg Today 2010;40:883)
● Male predominance, age ranges from newborn to 66 years; 1-25 cm, solitary

● Liver involvement is part of multicentric process affecting other organs, particularly spleen
● May be congenital or benign slow growing tumor derived from proliferating lymph ducts, inflammatory and fibrotic processes or genetic predisposition
● May represent mesenchymal hamartoma

Gross description
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● Well-defined solid and cystic tumor with or without spotty calcification

Gross images
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Cystic and smooth mass includes gallbladder

Micro description
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● Cystic tumor with colloid-like content and attenuated endothelial-like cells, no atypia

Micro images
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Multiple cystic spaces lined by endothelium

Positive stains
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● CD31, CD34, D2-40, LYVE-1, Prox-1

Differential diagnosis
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● Hemangioma: negative for lymphatic endothelial markers

End of Liver and intrahepatic bile ducts - Tumor > Benign tumors > Lymphangioma

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