Liver and intrahepatic bile ducts - tumor
Benign tumors / conditions

Topic Completed: 1 February 2012

Revised: 25 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Lymphangioma[TI] liver

Deepali Jain, M.D.
Page views in 2019: 422
Page views in 2020 to date: 125
Cite this page: Jain D. Lymphangioma. website. Accessed April 1st, 2020.
Definition / general
  • Very rare; < 25 cases reported (Hepatol Int 2010;4:784, Surg Today 2010;40:883)
  • Male predominance, age ranges from newborn to 66 years; 1 - 25 cm, solitary
  • Liver involvement is part of multicentric process affecting other organs, particularly spleen
  • May be congenital or benign slow growing tumor derived from proliferating lymph ducts, inflammatory and fibrotic processes or genetic predisposition
  • May represent mesenchymal hamartoma
Gross description
  • Well defined solid and cystic tumor with or without spotty calcification
Gross images

Images hosted on other servers:

Cystic and smooth mass includes gallbladder

Microscopic (histologic) description
  • Cystic tumor with colloid-like content and attenuated endothelial-like cells, no atypia
Microscopic (histologic) images

Images hosted on other servers:

Multiple cystic spaces lined by endothelium

Positive stains
Differential diagnosis
  • Hemangioma: negative for lymphatic endothelial markers
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