Liver and intrahepatic bile ducts - tumor
Benign tumors / conditions
Lymphangioma




Topic Completed: 1 February 2012

Revised: 25 January 2019, last major update February 2012

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PubMed Search: Lymphangioma[TI] liver

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Cite this page: Jain D. Lymphangioma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/livertumorlymphangioma.html. Accessed February 18th, 2019.
Definition / general
  • Very rare; < 25 cases reported (Hepatol Int 2010;4:784, Surg Today 2010;40:883)
  • Male predominance, age ranges from newborn to 66 years; 1 - 25 cm, solitary
  • Liver involvement is part of multicentric process affecting other organs, particularly spleen
  • May be congenital or benign slow growing tumor derived from proliferating lymph ducts, inflammatory and fibrotic processes or genetic predisposition
  • May represent mesenchymal hamartoma
Gross description
  • Well defined solid and cystic tumor with or without spotty calcification
Gross images

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Cystic and smooth mass includes gallbladder

Microscopic (histologic) description
  • Cystic tumor with colloid-like content and attenuated endothelial-like cells, no atypia
Microscopic (histologic) images

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Multiple cystic spaces lined by endothelium

Positive stains
Differential diagnosis
  • Hemangioma: negative for lymphatic endothelial markers