Liver and intrahepatic bile ducts - tumor
Other malignancies

Topic Completed: 1 February 2012

Revised: 28 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Mastocytosis[TI] liver[mh]

See also: Chronic myeloid neoplasms chapter

Deepali Jain, M.D.
Page views in 2018: 55
Page views in 2019 to date: 47
Cite this page: Jain D. Mastocytosis. website. Accessed September 19th, 2019.
Definition / general
  • Mast cell disorders have variable symptoms of diarrhea, weight loss, weakness, fractures or osteoporosis in 25%, arthralgia, flushing, bronchospasm
  • 40 - 60% of cases have hepatic involvement
  • May present as cholestatic disorder
  • Associated with obliterative portal venopathy, venoocclusive disease, nodular regenerative hyperplasia, cirrhosis
Microscopic (histologic) description
  • Round or spindled, degranulated mast cells in portal tracts and sinusoids; may be subtle
  • Usually also portal fibrosis, 50% have extramedullary hematopoiesis
Microscopic (histologic) images

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Various images

Positive stains
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