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Liver and intrahepatic bile ducts - tumor

Other malignancies

Mastocytosis


Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

See also Chronic myeloid neoplasms chapter

General
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● Mast cell disorders have variable symptoms of diarrhea, weight loss, weakness, fractures or osteoporosis in 25%, arthralgia, flushing, bronchospasm
● 40-60% of cases have hepatic involvement
● May present as cholestatic disorder
● Associated with obliterative portal venopathy, venoocclusive disease, nodular regenerative hyperplasia, cirrhosis

Micro description
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● Round or spindled, degranulated mast cells in portal tracts and sinusoids; may be subtle
● Usually also portal fibrosis, 50% have extramedullary hematopoiesis

Micro images
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Various images

Positive stains
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● Tryptase, Leder stain

End of Liver and intrahepatic bile ducts - tumor > Other malignancies > Mastocytosis


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