Liver and intrahepatic bile ducts - tumor
Other malignancies
Mastocytosis

Author: Deepali Jain, M.D. (see Authors page)

Revised: 5 December 2017, last major update February 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Mastocytosis[TI] liver[mh]

See also: Chronic myeloid neoplasms chapter
Cite this page: Jain, D. Mastocytosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/livertumormastocytosis.html. Accessed December 13th, 2017.
Definition / general
  • Mast cell disorders have variable symptoms of diarrhea, weight loss, weakness, fractures or osteoporosis in 25%, arthralgia, flushing, bronchospasm
  • 40 - 60% of cases have hepatic involvement
  • May present as cholestatic disorder
  • Associated with obliterative portal venopathy, venoocclusive disease, nodular regenerative hyperplasia, cirrhosis
Microscopic (histologic) description
  • Round or spindled, degranulated mast cells in portal tracts and sinusoids; may be subtle
  • Usually also portal fibrosis, 50% have extramedullary hematopoiesis
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains