Liver and intrahepatic bile ducts - tumor - Nodal CD8+ cytotoxic peripheral T-cell lymphoma

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Liver and intrahepatic bile ducts - tumor

Leukemia / lymphoma

Nodal CD8+ cytotoxic peripheral T-cell lymphoma

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

See also Lymphoma and plasma cell neoplasms chapter

General
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● Most peripheral T-cell lymphomas are CD4+; CD8+ tumors are rare
● Associated with disseminated intravascular coagulation (DIC) and hemophagocytic syndrome
● Poor prognosis
● Sites: lymph node (all), liver, bone marrow and CNS

Case reports
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● Four men and seven women aged 5 to 82 years (Mod Pathol 2002;15:1131)

Micro description
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● Neoplastic cells (small to large) with irregular / elongated nucleus with dense chromatin and indistinct nucleoli; also macrophages containing necrotic material

Micro images
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Large cells and small cleaved cells

CD8 Perforin Granzyme B TIA1

Positive stains
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● CD3, CD8, perforin, TIA1 and granzyme B

End of Liver and intrahepatic bile ducts - tumor > Leukemia / lymphoma > Nodal CD8+ cytotoxic peripheral T-cell lymphoma

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