Liver and intrahepatic bile ducts - tumor
Leukemia / lymphoma
Nodal CD8+ cytotoxic peripheral T cell lymphoma

Topic Completed: 1 February 2012

Revised: 28 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Nodal CD8+ cytotoxic peripheral T cell lymphoma

See also: Lymphoma and plasma cell neoplasms chapter

Deepali Jain, M.D.
Page views in 2018: 63
Page views in 2019 to date: 76
Cite this page: Jain D. Nodal CD8+ cytotoxic peripheral T cell lymphoma. website. Accessed December 9th, 2019.
Definition / general
  • Most peripheral T cell lymphomas are CD4+; CD8+ tumors are rare
  • Associated with disseminated intravascular coagulation (DIC) and hemophagocytic syndrome
  • Poor prognosis
  • Lymph node (all), liver, bone marrow and CNS
Case reports
Microscopic (histologic) description
  • Neoplastic cells (small to large) with irregular / elongated nucleus with dense chromatin and indistinct nucleoli; also macrophages containing necrotic material
Positive stains
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