Liver and intrahepatic bile ducts - tumor
Hepatocellular carcinoma
Pleomorphic (giant cell) variant

Topic Completed: 1 February 2012

Revised: 25 April 2019

Revised: 25 January 2019, last major update February 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Pleomorphic[TI] OR giant cell[TI] hepatocellular carcinoma

Deepali Jain, M.D.
Page views in 2018: 798
Page views in 2019 to date: 447
Cite this page: Jain D. Pleomorphic (giant cell) variant of hepatocellular carcinoma. website. Accessed September 24th, 2019.
Definition / general
  • < 1% of all hepatocellular carcinomas, although 15% have some tumor giant cells
  • Multinucleated tumor giant cells predominate, marked loss of cell cohesion (Am J Clin Pathol 1990;93:111)
Case reports
Gross images

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Multifocal gray tumor nodules in cirrhotic liver

Microscopic (histologic) images

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Pleomorphic tumor giant cells in background of cirrhosis

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