Liver and intrahepatic bile ducts - tumor - Pleomorphic (giant cell) variant of hepatocellular carcinoma

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Liver and intrahepatic bile ducts - tumor

Hepatocellular carcinoma

Pleomorphic (giant cell) variant of hepatocellular carcinoma

Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● < 1% of all hepatocellular carcinomas, although 15% have some tumor giant cells
● Multinucleated tumor giant cells predominate, marked loss of cell cohesion (Am J Clin Pathol 1990;93:111)

Case reports
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● Infant with syncytial giant cell variant (Ann Diagn Pathol 2007;11:61)
● 50 year old man presenting with atrial metastasis (Indian J Pathol Microbiol 2011;54:632)

Gross images
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Multifocal gray tumor nodules in cirrhotic liver

Micro images
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Pleomorphic tumor giant cells in background of cirrhosis

Pleomorphic tumor giant cells

End of Liver and intrahepatic bile ducts - tumor > Hepatocellular carcinoma > Pleomorphic (giant cell) variant of hepatocellular carcinoma

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