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Liver and intrahepatic bile ducts - Tumor

Benign tumors

Reactive bile ductule proliferation


Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● Bile ductular proliferation due to ductular metaplasia of hepatocytes and from proliferation of pre-existing bile ductules
● Associated with cirrhosis, submassive hepatic necrosis, biliary tract disorders, atrophy and focal nodular hyperplasia

Gross description
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● Often multiple irregular nodules

Micro description
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● Periductular neutrophils common
● No angulated structures, usually no dense fibrosis (except with atrophy), variable bile in portal tract or periportal area

Positive stainss
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● Neuroendocrine stains (Am J Pathol 1990;137:1019)

Differential diagnosis
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● Adenocarcinoma: particularly confusing after chemotherapy, has more severe atypia with irregular nuclear membranes, prominent nucleoli, hyperchromasia, increased N/C ratio, desmoplasia, infiltrative cells
● Bile duct adenoma: solitary, subcapsular, with collapsed lumina, prominent lymphocytes
● Bile duct hamartoma: angulated ducts embedded in sclerotic stroma

End of Liver and intrahepatic bile ducts - Tumor > Benign tumors > Reactive bile ductule proliferation


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