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Liver and intrahepatic bile ducts - tumor

Benign tumors / conditions

Reactive lymphoid hyperplasia / pseudolymphoma


Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.

General
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● Also called pseudolymphoma, may mimic lymphoma (Mod Pathol 2010;23:244, Am J Surg Pathol 1999;23:302)
● Rare, < 50 cases reported
● Age range 1581 years; female predominance
● Usually incidental finding, right lobe predilection
● Associated with chronic liver disease, extrahepatic autoimmune disorders and malignancies
● May be concomitant hepatic and pancreatic involvement (Clin Res Hepatol Gastroenterol 2012;36:e71)
● May be immune mediated
● No associated systemic manifestations
● Resection is curative

Case reports
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● 69 year old woman with stage I renal cell carcinoma and hepatic mass (Arch Pathol Lab Med 2001;125:577)

Gross description
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● Well-circumscribed, tan, non-encapsulated, solitary (multiple in 20%) rubbery nodule, 0.5-5.5 cm

Micro description
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● Prominent lymphoid follicles with germinal centers, tingible-body macrophages and polymorphic small lymphocytes

Micro images
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Various images

Positive stains
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● CD20

Negative stains
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● BCL2 does not stain germinal centers; no light chain restriction

Differential diagnosis
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Autoimmune hepatitis
Castleman's disease
● Chronic hepatitis B or Hepatitis C infection
MALT or other low grade lymphoma - lymphoepithelial lesions, cellular atypia, light chain restriction
Primary biliary cirrhosis

End of Liver and intrahepatic bile ducts - tumor > Benign tumors / conditions > Reactive lymphoid hyperplasia / pseudolymphoma


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