Liver and intrahepatic bile ducts - tumor
Sarcomatoid variant of hepatocellular carcinoma
Reviewers: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update February 2012
Copyright: (c) 2004-2013, PathologyOutlines.com, Inc.
● Also called spindle cell hepatocellular carcinoma, pseudosarcomatous
● Diffuse collection of spindle cells resembling fibrosarcoma or malignant fibrous histiocytoma, but with classic hepatocellular carcinoma is also present
● Note: 1-9% of all hepatocellular carcinomas have prominent sarcomatoid pattern
● Mean age 62 years old, range 46-84 years, usually men
● Metastases common, often to lung and lymph nodes
● Most patients die of disease
● Diffuse collection of spindle cells resembling fibrosarcoma or malignant fibrous histiocytoma
● Classic hepatocellular carcinoma is also present
● May have pleomorphic and osteoclast-like giant cells, chondroid differentiation (Pathol Int 2000;50:919)
● Cytokeratin (60%), alpha fetoprotein
● Variable HHF35, smooth muscle actin, desmin, CD68 and S100
● Collision tumor
● Carcinoma with foci of spindle shaped epithelial cells
End of Liver and intrahepatic bile ducts - tumor > Hepatocellular carcinoma > Sarcomatoid variant of hepatocellular carcinoma
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