Liver & intrahepatic bile ducts
General
WHO classification
Author: Raul S. Gonzalez, M.D.
Editor-in-Chief: Debra L. Zynger, M.D.
Last author update: 10 December 2020
Last staff update: 22 February 2024
Copyright: 2020-2024, PathologyOutlines.com, Inc.
PubMed Search: WHO classification liver
Cite this page: Gonzalez RS. WHO classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/liverwhoclassification.html. Accessed April 24th, 2024.
Definition / general
- WHO classification of tumors of the liver and intrahepatic bile ducts
- Currently on 5th edition, published in 2019
- Based on histologic appearance, not molecular characteristics
WHO (2019)
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Benign hepatocellular tumors ICD-O codes
- Hepatocellular adenoma 8170/0
- HNF1A inactivated hepatocellular adenoma
- Inflammatory hepatocellular adenoma
- B-catenin activated hepatocellular adenoma
- B-catenin activated inflammatory hepatocellular adenoma
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Malignant hepatocellular tumors and precursors ICD-O codes
- Hepatocellular carcinoma, NOS 8170/3
- Hepatocellular carcinoma, fibrolamellar 8171/3
- Hepatocellular carcinoma, scirrhous 8172/3
- Hepatocellular carcinoma, clear cell type 8174/3
- Hepatocellular carcinoma, steatohepatitic
- Hepatocellular carcinoma, macrotrabecular massive
- Hepatocellular carcinoma, chromophobe
- Hepatocellular carcinoma, neutrophil rich
- Hepatocellular carcinoma, lymphocyte rich
- Hepatoblastoma, NOS 8970/3
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Benign biliary tumors and precursors ICD-O codes
- Bile duct adenoma 8160/0
- Adenofibroma, NOS 9013/0
- Biliary intraepithelial neoplasia, low grade 8148/0
- Biliary intraepithelial neoplasia, high grade 8148/2
- Intraductal papillary neoplasm with low grade intraepithelial neoplasia 8503/0
- Intraductal papillary neoplasm with high grade intraepithelial neoplasia 8503/2
- Intraductal papillary neoplasm with associated invasive carcinoma 8503/3
- Mucinous cystic neoplasm with low grade intraepithelial neoplasia 8470/0
- Mucinous cystic neoplasm with high grade intraepithelial neoplasia 8470/2
- Mucinous cystic neoplasm with associated invasive carcinoma 8470/3
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Malignant biliary tumors ICD-O codes
- Cholangiocarcinoma 8160/3
- Large duct intrahepatic cholangiocarcinoma
- Small duct intrahepatic cholangiocarcinoma
- Carcinoma, undifferentiated, NOS 8020/3
- Combined hepatocellular carcinoma and cholangiocarcinoma 8180/3
- Neuroendocrine tumor, NOS 8240/3
- Neuroendocrine tumor, grade 1 8240/3
- Neuroendocrine tumor, grade 2 8249/3
- Neuroendocrine tumor, grade 3 8249/3
- Neuroendocrine carcinoma, NOS 8246/3
- Large cell neuroendocrine carcinoma 8013/3
- Small cell neuroendocrine carcinoma 8041/3
- Mixed neuroendocrine - nonneuroendocrine neoplasm (MiNEN) 8154/3
