Other interstitial pneumonitis / fibrosis
Cryptogenic organizing pneumonia (Bronchiolitis obliterans-organizing pneumonia, BOOP)
Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 24 September 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Common response to infectious or inflammatory injury to lungs
● Also associated with drugs, collagen vascular disease, and graft versus host disease in bone marrow transplant patients
● Cause cannot be determined from biopsy - requires clinical history
● Acute onset with cough, shortness of breath, fever and malaise
● Excellent prognosis, but steroid resistance may lead to death
● Steroids, however, some patients have self-limited disease
● Patchy fibroblastic plugs in bronchioles and alveolar ducts (bronchiolitis obliterans) and alveoli (organizing pneumonia)
● Plugs formed by spindled fibroblasts in pale-staining matrix with serpiginous or elongated shape
● Also foamy macrophages, thickened alveolar septa and rare neutrophils
● Low power: evenly spaced nodules or plugs of organizing connective tissue and inflammation that obliterates terminal airways
End of Lung-nontumor > Other interstitial pneumonitis / fibrosis > Cryptogenic organizing pneumonia (Bronchiolitis obliterans-organizing pneumonia, BOOP)
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