Lung - nontumor
Chronic obstructive pulmonary disease (COPD)
COPD - General

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 22 February 2017, last major update August 2011

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed search: copd [title] general lungs

Table of Contents
Definition / general
Cite this page: COPD - General. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungnontumorCOPDgeneral.html. Accessed August 17th, 2017.
Definition / general
  • Also called chronic obstructive lung disease (COLD) (Wikipedia)
  • Two major forms are chronic bronchitis (chronic large airway disease) and emphysema; they may coexist
  • Major cause of bed defining disability and death in US
  • Major symptom is dyspnea (shortness of breath)
  • Usually due to cigarette smoking
  • Sites of disease:
    • Bronchi: chronic bronchitis, bronchiectasis and asthma
    • Bronchioles: bronchiolitis
    • Acini: emphysema
  • Obstructive airway disease: increase in resistance to airflow due to obstruction at any level; includes emphysema, chronic bronchitis, bronchiectasis, asthma, tumor, foreign body; have reduced maximal airflow rates (FEV1); although isolated chronic bronchitis does not show reduced FEV1, coexisting emphysema or small airway disease is usually present
  • Restrictive airway disease: reduced expansion of lung parenchyma with decrease in total lung capacity; normal FEV1; due to chest wall disorders (polio, obesity, pleural disease, kyphoscoliosis) and interstitial / infiltrative diseases (ARDS, dust diseases, interstitial fibrosis)