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Other non-neoplastic disease

Inflammatory bowel disease (IBD)

Reviewers: Dr. Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 9 November 2011, last major update October 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● Vast majority of patients with lung disease have history of IBD in GI tract, but lung disease may occur without GI disease
● Lung involvement more common with ulcerative colitis than Crohn’s disease
● Acute or chronic bronchiolitis with non-necrotizing granulomas, bronchopneumonia, interstitial pneumonia and organizing pneumonia
● May be due to mesalamine (anti-inflammatory component of sulfasalazine, used to treat IBD)
● May have CMV or atypical mycobacteria infections

Differential diagnosis

● Sarcoidosis: lymphangitic distribution, no interstitial pneumonia and no chronic bronchiolitis
● Hypersensitivity pneumonia: different history

Additional references

Am J Surg Pathol 2003;27:213

End of Lung-nontumor > Other non-neoplastic disease > Inflammatory bowel disease (IBD)

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