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Lung-nontumor

Other interstitial pneumonitis / fibrosis

PVP


Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 25 September 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
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● Crospovidone, a N-vinyl-2-pyrrolidone polymer, is used as a disintegrant in pharmaceutical tablets
● May embolize to lung if injected IV

Micro description
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● Deeply basophilic, coral-like particles within pulmonary arteries and in extravascular foreign-body granulomas
● Associated with inflammatory cells

Micro images
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Embolized crospovidone

Positive stains
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● Movat pentachrome (orange-yellow)

Negative stains
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● Alcian blue

EM description
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● Irregular, electron dense, laminated finely granular material

EM images
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Intrapulmonary crospovidone

Additional References
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Mod Pathol 2003;16:286

End of Lung-nontumor > Other interstitial pneumonitis / fibrosis > PVP


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