Lung nontumor
Granulomatous (non-infectious) inflammation
Allergic granulomatosis and angiitis


Topic Completed: 1 September 2011

Revised: 29 January 2019, last major update September 2011

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PubMed search: allergic [title] granulomatosis angiitis pulmonary


Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Allergic granulomatosis and angiitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungnontumorallergicgran.html. Accessed July 8th, 2020.
Definition / general
  • Also called Churg-Strauss syndrome
  • Very rare
  • Systemic vasculitis resembling polyarteritis nodosa or microscopic polyangiitis; associated with asthma, peripheral eosinophilia, pulmonary involvement and fever
  • Rarely presents without pulmonary disease as fever of unknown origin
  • < 50% have positive ANCA, often antimyeloperoxidase
Treatment
  • Steroids: effective, but patients may relapse
Microscopic (histologic) description
  • Lung and extrapulmonary sites (skin, heart, nervous system, GI) have prominent eosinophilic infiltrate, granulomatous reaction around necrotic foci with radially arranged histiocytes and pallisading giant cells near small arteries or arterioles, eosinophilic vasculitis
  • May have fibrin rich edema, lymphocytes, sarcoid-like granulomas, focal fibrosis and eosinophilic microabscesses
Differential diagnosis
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