Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 4 September 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● See also Skin-nontumor chapter
● Dimorphic fungus found in soil in Central and Southeastern United States and Canada (bordering Great Lakes, St. Lawrence River, Mississippi River and Ohio River basins), Mexico, Africa, India, Middle East
● More common in males
● Due to inhalation of soil containing microfoci of mycelia (Clin Microbiol Rev 2010;23:367)
● Difficult to isolate in clinical microbiology laboratory
● May present as consolidative pneumonia, ARDS or nodules resembling carcinoma; prefers upper lobes
● May also infect skin and bone
● Grossly often resembles tuberculosis
● Mixed acute and granulomatous inflammation caused by large budding yeasts (15-10 um) with broad based buds and refractile walls, easily seen with H&E
Various images (skin or sputum)
End of Lung-nontumor > Infections > Blastomyces
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