Lung - nontumor
Granulomatous inflammation (noninfectious)
Bronchocentric granulomatosis

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 28 February 2017, last major update September 2011

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PubMed search: bronchocentric granulomatosis

Cite this page: Bronchocentric granulomatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungnontumorbronchocentric.html. Accessed December 11th, 2017.
Definition / general
  • Granulomatous disease of lungs in which almost all granulomas are centered in bronchi or bronchioles causing their destruction
  • Immunologic reaction related to chronic eosinophilic pneumonia and allergic bronchopulmonary aspergillosis
  • A histologic pattern of disease, not a specific diagnosis
  • Usually adults, often with asthma history and limited to lungs, may be asymptomatic
  • Usually solitary lesions that appear on chest Xray as atelectasis or consolidation, not nodules
  • Generally favorable prognosis
Gross description
  • Viscous material in involved bronchi
Microscopic (histologic) description
  • Large and medium bronchi infiltrated by neutrophils, eosinophils and necrotic debris surrounded by foreign body giant cells
  • Fragmented elastic tissue (with elastic stain)
  • Also bronchiolitis obliterans
  • No fibrinoid necrosis of vessels
Differential diagnosis