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Other interstitial pneumonitis / fibrosis

Diffuse panbronchiolitis

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 24 September 2011, last major update September 2011
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● Rare, usually Japanese, other Asians, rarely others
● Patients typically have history of sinusitis
● Associated with HLA BW54, Haemophilus influenza or Pseudomonas aeruginosa infection
● Chronic, progressive obstructive and suppurative airway disease
● Without treatment, progression to bronchiectasis and respiratory failure, worse course with Pseudomonas infection


● Antibiotics, generally good response to long term macrolide treatment
● Patients also benefit from antiinflammatory effect of medication

Micro description

● Foamy macrophages in pulmonary interstitium, chronic inflammation in terminal bronchioles

End of Lung-nontumor > Other interstitial pneumonitis / fibrosis > Diffuse panbronchiolitis

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