Lung - nontumor
Other interstitial pneumonitis / fibrosis
Diffuse panbronchiolitis



Topic Completed: 1 September 2011

Revised: 30 January 2019, last major update September 2011

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PubMed search: diffuse panbronchiolitis [title]


Elliot Weisenberg, M.D.
Page views in 2018: 223
Page views in 2019 to date: 155
Cite this page: Weisenberg E. Diffuse panbronchiolitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungnontumordiffusepanbronch.html. Accessed July 22nd, 2019.
Definition / general
  • Rare, usually Japanese, other Asians, rarely others
  • Patients typically have history of sinusitis
  • Associated with HLA BW54, Haemophilus influenzae or Pseudomonas aeruginosa infection
  • Chronic, progressive obstructive and suppurative airway disease
  • Without treatment, progression to bronchiectasis and respiratory failure, worse course with Pseudomonas infection
Treatment
  • Antibiotics, generally good response to long term macrolide treatment
  • Patients also benefit from anti-inflammatory effect of medication
Microscopic (histologic) description
  • Foamy macrophages in pulmonary interstitium, chronic inflammation in terminal bronchioles
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