Lung - nontumor
Other interstitial pneumonitis / fibrosis
Diffuse panbronchiolitis

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 28 February 2017, last major update September 2011

Copyright: (c) 2003-2017,, Inc.

PubMed search: diffuse panbronchiolitis [title]

Cite this page: Diffuse panbronchiolitis. website. Accessed April 24th, 2017.
Definition / General
  • Rare, usually Japanese, other Asians, rarely others
  • Patients typically have history of sinusitis
  • Associated with HLA BW54, Haemophilus influenzae or Pseudomonas aeruginosa infection
  • Chronic, progressive obstructive and suppurative airway disease
  • Without treatment, progression to bronchiectasis and respiratory failure, worse course with Pseudomonas infection
  • Antibiotics, generally good response to long term macrolide treatment
  • Patients also benefit from anti-inflammatory effect of medication
Micro Description
  • Foamy macrophages in pulmonary interstitium, chronic inflammation in terminal bronchioles