Lung - nontumor
Infections
Hantavirus pneumonia

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 24 February 2017, last major update September 2011

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed search: hantavirus [title] pneumonia

Cite this page: Hantavirus pneumonia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungnontumorhantavirus.html. Accessed July 20th, 2017.
Clinical features
  • Zoonosis transmitted by feces from infected rodents (Emerg Infect Dis 2009;15:561)
  • Severe pulmonary disease, often in Southwest US; 25% - 35% mortality
  • Symptoms eventually resolve in almost all survivors (Lung 2010;188;387)
  • Epidemic disease occurred in Southwestern US in 1993 (Centers for Disease Control); sporadic cases have occurred since then
  • Diagnosis confirmed by immunohistochemistry, serology, PCR, electron microscopy
Clinical images

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Cotton Rat (Sigmodon hispidus)

Microscopic (histologic) description
  • Causes interstitial pneumonitis with mononuclear infiltrate, edema, focal hyaline membranes, pleura effusions
  • Atypical lymphocytes in pulmonary vasculature may mimic lymphoma
Electron microscopy images

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Transmission electron
micrograph of Sin
Nombre Hantavirus

Additional references