Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 5 September 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Zoonosis transmitted by feces from infected rodents (Emerg Infect Dis 2009;15:561)
● Severe pulmonary disease, often in Southwest US; 25-35% mortality
● Symptoms eventually resolve in almost all survivors (Lung 2010;188;387)
● Epidemic disease occurred in Southwestern US in 1993 (Centers for Disease Control); sporadic cases have occurred since then
● Diagnosis confirmed by immunohistochemistry, serology, PCR, electron microscopy
Cotton Rat (Sigmodon hispidus)
● Causes interstitial pneumonitis with mononuclear infiltrate, edema, focal hyaline membranes, pleura effusions
● Atypical lymphocytes in pulmonary vasculature may mimic lymphoma
Interstitial pneumonitis and intraalveolar edema
Electron microscopy images
Transmission electron micrograph of Sin Nombre Hantavirus
End of Lung-nontumor > Infections > Hantavirus pneumonia
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