Lung - nontumor
Other interstitial pneumonitis / fibrosis
Honeycomb lung

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 1 March 2017, last major update September 2011

Copyright: (c) 2003-2017,, Inc.

PubMed search: honeycomb lung [title]

Cite this page: Honeycomb lung. website. Accessed December 11th, 2018.
Definition / general
  • Final common pathway of various processes causing chronic interstitial fibrosis
  • Progressive shortness of breath, severe interstitial fibrosis, diffuse cystic changes with blebs and subsequent pneumothorax and shrunken lungs (restrictive lung disease) with elevation of diaphragm
Gross description
  • Stiff, spongy and fibrotic lungs with cystic changes
Gross images

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Honeycomb lung

Microscopic (histologic) description
  • Dense interstitial and peribronchial fibrosis and smooth muscle
  • Reduced alveolar capillaries
  • Marked medial hyperplasia of pulmonary arteries and arterioles
  • Cystically dilated alveoli
  • May have mucinous metaplasia of lining epithelium with atypia