Lung - nontumor
Other interstitial pneumonitis / fibrosis
Honeycomb lung

Topic Completed: 1 September 2011

Revised: 30 January 2019, last major update September 2011

Copyright: (c) 2003-2017,, Inc.

PubMed search: honeycomb lung [title]

Elliot Weisenberg, M.D.
Page views in 2019: 1,622
Page views in 2020 to date: 666
Cite this page: Weisenberg E. Honeycomb lung. website. Accessed June 4th, 2020.
Definition / general
  • Final common pathway of various processes causing chronic interstitial fibrosis
  • Progressive shortness of breath, severe interstitial fibrosis, diffuse cystic changes with blebs and subsequent pneumothorax and shrunken lungs (restrictive lung disease) with elevation of diaphragm
Gross description
  • Stiff, spongy and fibrotic lungs with cystic changes
Gross images

Images hosted on other servers:

Honeycomb lung

Microscopic (histologic) description
  • Dense interstitial and peribronchial fibrosis and smooth muscle
  • Reduced alveolar capillaries
  • Marked medial hyperplasia of pulmonary arteries and arterioles
  • Cystically dilated alveoli
  • May have mucinous metaplasia of lining epithelium with atypia
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