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Other interstitial pneumonitis / fibrosis

Honeycomb lung

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 25 September 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● Final common pathway of various processes causing chronic interstitial fibrosis
● Progressive shortness of breath, severe interstitial fibrosis, diffuse cystic changes with blebs and subsequent pneumothorax and shrunken lungs (restrictive lung disease) with elevation of diaphragm

Gross description

● Stiff, spongy and fibrotic lungs with cystic changes

Gross images

Honeycomb lung

Micro description

● Dense interstitial and peribronchial fibrosis and smooth muscle
● Reduced alveolar capillaries
● Marked medial hyperplasia of pulmonary arteries and arterioles
● Cystically dilated alveoli
● May have mucinous metaplasia of lining epithelium with atypia

End of Lung-nontumor > Other interstitial pneumonitis / fibrosis > Honeycomb lung

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