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Lung-nontumor

Other non-neoplastic disease

Idiopathic pulmonary hemosiderosis


Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 17 December 2011, last major update December 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

General
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● Rare, usually children or teenagers with hemoptysis, hypoxemia, dypsnea and iron deficiency anemia similar to Goodpastures disease, but no antibodies in serum or tissue, no renal disease
● Clinical triad of hemoptysis, iron deficiency and diffuse pulmonary infiltrates
● May be related to consanguinity or environmental factors
● Fever, lymph node, liver and spleen enlargement may occur
● Usually fatal after several years
● Diagnosis of exclusion

Micro description
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● Hemosiderin laden macrophages in alveolar lumina, shedding and hyperplasia of alveolar epithelial cells and marked alveolar capillary congestion
● Varying interstitial fibrosis, intra-alveolar hemorrhage
● No necrosis, no vasculitis, no granulomas and no lymphoid follicles

Differential diagnosis
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Note: these disorders all cause secondary pulmonary alveolar bleeding and hemosiderosis
● Mitral stenosis
● Periarteritis nodosa
● SLE (neutrophils in alveolar septal capillaries)
● Systemic vasculitis

End of Lung-nontumor > Other non-neoplastic disease > Idiopathic pulmonary hemosiderosis


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