Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Lung-nontumor

Infections

Nocardia


Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 2 February 2012, last major update September 2011
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

Clinical features
=========================================================================

● Ubiquitous saphrophyte; disease caused by inhalation or direct implantation into skin
● More than 30 species with clinical significance (Clin Microbiol Rev 2006;19:259)
● Opportunistic lung infection associated with transplantation, chemotherapy, immunosuppression, steroids
● Disease is relatively uncommon in HIV likely due to sulfonamide prophylaxis directed against P. jeroveci; HAART treatment may be effective (Can J Infect Dis Med Microbiol 2009;20:e103)
● Complication of alveolar proteinosis

Clinical images
=========================================================================



White colonies

Gross images
=========================================================================



Abscess

Micro description
=========================================================================

● Focal bronchopneumonia with microabscesses, variable histiocytic response and ill-defined granulomas
● If identified by anatomic pathologist, clinical microbiology laboratory should be notified as routine culture may not isolate the organism

Micro images
=========================================================================



Small abscess


Nocardia brasiliensis

   
Gram stain


Modified acid fast stain shows weakly acid fast branching, filamentous bacilli


Modified Fite stain

Positive stains
=========================================================================

● Modified acid fast, Fite, gram stain and GMS
Gram stain: slender, slightly beaded, branching filamentous bacilli

End of Lung-nontumor > Infections > Nocardia


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).