Pulmonary mycotoxicosis (organic dust syndrome)
Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 26 September 2011, last major update September 2011
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● Mechanism of lung injury unclear, not due to hypersensitivity
● Associated with grain silos, but different from silo-fillerís disease
● Upper part of silo is relatively anaerobic with a high pH, an excellent environment for fungal growth
● When upper layer is emptied, workers at risk of exposure to large numbers of fungal hyphae and spores
● Patients rapidly develop cough, dypsnea, chest tightness, headache and fever
● Most patients recover completely
● Rarely biopsied; may show fungal spores, obliterative bronchiolitis, acute bronchopneumonia or diffuse alveolar damage
End of Lung-nontumor > Pneumoconiosis > Pulmonary mycotoxicosis (Organic dust syndrome)
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