Lung - nontumor
Pulmonary mycotoxicosis (organic dust syndrome)

Topic Completed: 1 September 2011

Revised: 30 January 2019, last major update September 2011

Copyright: (c) 2003-2017,, Inc.

PubMed search: pulmonary mycotoxicosis, organic dust syndrome [title]

Elliot Weisenberg, M.D.
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Table of Contents
Definition / general
Cite this page: Weisenberg E. Pulmonary mycotoxicosis (Organic dust syndrome). website. Accessed May 28th, 2020.
Definition / general
  • Mechanism of lung injury unclear, not due to hypersensitivity
  • Associated with grain silos, but different from silo filler's disease
  • Upper part of silo is relatively anaerobic with a high pH, an excellent environment for fungal growth
  • When upper layer is emptied, workers at risk of exposure to large numbers of fungal hyphae and spores
  • Patients rapidly develop cough, dypsnea, chest tightness, headache and fever
  • Most patients recover completely
  • Rarely biopsied; may show fungal spores, obliterative bronchiolitis, acute bronchopneumonia or diffuse alveolar damage
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