Lung - nontumor
Pulmonary mycotoxicosis (organic dust syndrome)

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 1 March 2017, last major update September 2011

Copyright: (c) 2003-2017,, Inc.

PubMed search: pulmonary mycotoxicosis, organic dust syndrome [title]

Table of Contents
Definition / general
Cite this page: Pulmonary mycotoxicosis (Organic dust syndrome). website. Accessed November 18th, 2018.
Definition / general
  • Mechanism of lung injury unclear, not due to hypersensitivity
  • Associated with grain silos, but different from silo filler's disease
  • Upper part of silo is relatively anaerobic with a high pH, an excellent environment for fungal growth
  • When upper layer is emptied, workers at risk of exposure to large numbers of fungal hyphae and spores
  • Patients rapidly develop cough, dypsnea, chest tightness, headache and fever
  • Most patients recover completely
  • Rarely biopsied; may show fungal spores, obliterative bronchiolitis, acute bronchopneumonia or diffuse alveolar damage