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Pulmonary mycotoxicosis (organic dust syndrome)

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 26 September 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● Mechanism of lung injury unclear, not due to hypersensitivity
● Associated with grain silos, but different from silo-fillerís disease
● Upper part of silo is relatively anaerobic with a high pH, an excellent environment for fungal growth
● When upper layer is emptied, workers at risk of exposure to large numbers of fungal hyphae and spores
● Patients rapidly develop cough, dypsnea, chest tightness, headache and fever
● Most patients recover completely
● Rarely biopsied; may show fungal spores, obliterative bronchiolitis, acute bronchopneumonia or diffuse alveolar damage

End of Lung-nontumor > Pneumoconiosis > Pulmonary mycotoxicosis (Organic dust syndrome)

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