Lung - nontumor
Patterns of injury for nonneoplastic disease

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 22 March 2017, last major update August 2011

Copyright: (c) 2003-2017,, Inc.

PubMed search: "patterns of injury" pulmonary

Cite this page: Patterns of injury for nonneoplastic disease. website. Accessed September 26th, 2018.
Definition / general
  • Major categories of interstitial lung disease
  • Fibrosing: UIP, NSIP, COP, lung disease with connective tissue disease, pneumoconiosis, drug reaction, radiation pneumonitis
  • Granulomatous: sarcoidosis, hypersensitivity pneumonitis
  • Eosinophilic
  • Smoking related: DIP, respiratory bronchiolitis-associated interstitial lung disease
  • Other: pulmonary alveolar proteinosis
  • Source: Kumar et al.: Robbins and Cotran Pathologic Basis of Disease, 8th Edition, 2009

  • Intraalveolar reaction: DIP, pulmonary alveolar proteinosis, infection, extrinsic allergic alveolitis, chronic eosinophilic pneumonia
  • Small airway disease: bronchiolitis obliterans, respiratory bronchiolitis, mycoplasma infection, viral infection, extrinsic allergic alveolitis, eosinophilic pneumonia
  • Large airway disease: allergic bronchopulmonary aspergillosis, bronchocentric granulomatosis, TB, fungi, Wegener's
  • Granulomatous vasculitis: Wegener's, sarcoidosis, Churg-Strauss, bronchocentric granulomatosis, fungi, TB
  • Small vessel disease: primary pulmonary hypertension, thromboembolism, polyarteritis nodosa, veno-occlusive disease, Churg-Strauss syndrome
  • Hemorrhage: Goodpasture's, SLE, immune complex glomerulonephritis, idiopathic pulmonary hemosiderosis, Wegener's
  • Lymphoid infiltrates: lymphocytic interstitial pneumonia, lymphoma, lymphoid aggregates, extrinsic allergic alveolitis
  • Eosinophils: chronic eosinophilic pneumonia, Churg-Strauss syndrome, bronchocentric granulomatosis, Langerhans cell histiocytosis