Lung-nontumor - Patterns of injury for non-neoplastic disease

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Lung-nontumor

Patterns of injury for non-neoplastic disease

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 24 August 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

Definition
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● Major categories of interstitial lung disease
● Fibrosing: UIP, NSIP, COP, lung disease with connective tissue disease, pneumoconiosis, drug reaction, radiation pneumonitis
● Granulomatous: sarcoidosis, hypersensitivity pneumonitis
● Eosinophilic
● Smoking related: DIP, respiratory bronchiolitis-associated interstitial lung disease
● Other: pulmonary alveolar proteinosis
● Source: Robbins and Cotran Pathologic Basis of Disease (8th Ed), Saunders, 2009

● Intraalveolar reaction: DIP, pulmonary alveolar proteinosis, infection, extrinsic allergic alveolitis, chronic eosinophilic pneumonia
● Small-airway disease: bronchiolitis obliterans, respiratory bronchiolitis, mycoplasma infection, viral infection, extrinsic allergic alveolitis, eosinophilic pneumonia
● Large-airway disease: allergic bronchopulmonary aspergillosis, bronchocentric granulomatosis, TB, fungi, Wegener’s
● Granulomatous vasculitis: Wegener’s, sarcoidosis, Churg-Strauss, bronchocentric granulomatosis, fungi, TB
● Small vessel disease: primary pulmonary hypertension, thromboembolism, polyarteritis nodosa, veno-occlusive disease, Churg-Strauss syndrome
● Hemorrhage: Goodpasture’s, SLE, immune complex glomerulonephritis, idiopathic pulmonary hemosiderosis, Wegener’s
● Lymphoid infiltrates: lymphocytic interstitial pneumonia, lymphoma, lymphoid aggregates, extrinsic allergic alveolitis
● Eosinophils: chronic eosinophilic pneumonia, Churg-Strauss syndrome, bronchocentric granulomatosis, Langerhans cell histiocytosis

Additional Reference
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● Histology for Pathologists, (3rd Ed), Lippincott, 2007

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