Other non-neoplastic disease
Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 19 December 2011, last major update December 2011
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● Due to hemodynamic disturbances (cardiogenic) or local microvascular injury
● Due to increased hydrostatic pressure from congestive heart failure
● Lungs are wet and heavy, fluid initially at base of lower lobes because hydrostatic pressure is greater here
● Congestion, fluid and hemosiderin laden macrophages (heart failure cells) are present
● Later fibrosis and thickening of alveolar walls (brown induration of lung)
Local microvascular injury:
● Injury causes leakage of fluids and proteins into interstitial space, eventually into alveoli
● When diffuse, contributes to acute respiratory distress syndrome
End of Lung-nontumor > Other non-neoplastic disease > Pulmonary edema
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