Other interstitial pneumonitis / fibrosis
Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 25 September 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Common, almost always seen in cigarette smokers generally with 30+ pack year history
● May persist 5 years or more after quitting, often incidental finding (Am J Surg Pathol 2002;26:647)
● May cause cough and dyspnea, usually mild, which regresses after cigarette cessation
● Severe disease known as respiratory bronchiolitis-associated interstitial lung disease
● Focal chronic inflammation of terminal bronchioles and alveolar ducts with adjacent focal interstitial inflammation and fibrosis
● Histiocytes fill alveolar ducts and spaces, but are predominantly peribronchiolar
● Histiocyte cytoplasm contains brown-black-yellow granules (smokerís granules)
● DIP: no pigmented macrophages
End of Lung-nontumor > Other interstitial pneumonitis / fibrosis > Respiratory bronchiolitis
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).