Other non-neoplastic disease
Rheumatoid lung disease
Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 19 December 2011, last major update December 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Variable presentation of chronic pleuritis, effusion, diffuse interstitial fibrosis, intrapulmonary rheumatoid nodules, rheumatoid nodules with pneumoconiosis (Caplanís syndrome), pulmonary hypertension, bronchiolitis obliterans, amyloidosis and vasculitis
● Note: 30% with rheumatoid arthritis have abnormal pulmonary function
● Rheumatoid nodules are associated with active joint disease and elevated titers of rheumatoid factor
● Steroids (thus, must first rule out an infectious process)
● Pleural fibrosis, rheumatoid nodules and pneumonia
● Rheumatoid granuloma usually in lung periphery near pleura
● Round with zone of pallisading histiocytes perpendicular to necrobiotic center
● Adjacent vasculitis
● Nodules have carbon and silica within the necrotic center in Caplanís syndrome
Nodules with central necrosis and pallisading histiocytes
● Wegenerís granulomatosis
End of Lung-nontumor > Other non-neoplastic disease > Rheumatoid lung disease
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