Lung - nontumor
Infections
Rhodococcus



Topic Completed: 1 September 2011

Revised: 29 January 2019, last major update September 2011

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PubMed search: Rhodococcus [title] pulmonary


Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Rhodococcus. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungnontumorrhodo.html. Accessed July 18th, 2019.
Clinical features
  • Zoonotic infection originally identified in lungs of foals; also cattle, swine, sheep, deer, goats, dogs, cats, other species
  • Worldwide distribution in water and soil, especially near feces of herbivores
  • Infection by inhalation or ingestion
  • Resides primarily within lung macrophages of infected patients, also some alveolar cells (Microbes Infect 2011;13:438)
  • R. equi is most common human pathogen of the Rhodococci
  • Generally occurs in AIDS patients (may cause malakoplakia, Clin Infect Dis 1999;28:1334); also other immunodeficient patients; very rarely in immunocompetent
  • Incidence decreasing, likely due to HAART therapy and azithromycin prophylaxis
  • "Rhodo" since salmon pink pigment in culture
  • Treated with antibiotics, but mortality is 50% in AIDS patients, 20% in other immunocompromised and 10% in immunocompetent
Case reports
Gross images

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Pulmonary mass in patient post renal transplant

Microscopic (histologic) description
  • Epithelioid macrophages containing gram positive, partially acid fast coccobacilli that resemble mycobacteria
  • May produce malakoplakia
Microscopic (histologic) images

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Various images

Figures 2 / 3: gram stain; 4: autopsy

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