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Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 25 September 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

See also Skin-nontumor chapter

Clinical features

● Pulmonary involvement rare in secondary syphilis
● In tertiary syphilis, nodular (gummatous) and fibrotic lesions of the lung (usually with pleural involvement) are well established yet uncommon (Chest 2004;125:2322)

Case reports

● Premature newborn with congenital syphilis, acute hyaline membrane disease and bilateral lung abscesses with spirochetes (Arch Pathol Lab Med 2002;126:484)
● 34 year old HIV+ man with secondary pulmonary syphilis (Clin Infect Dis 2006;42:e11)


● Penicillin

Gross/Micro images

Lung with uniform consolidated surface and 2 well-delineated, peripheral, white-yellow lesions; Figure 2: Warthin-Starry stain showing numerous spirochetes with characteristic coiling

Inguinal lymph node (different case)

End of Lung-nontumor > Infections > Syphilis

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