Adenoid cystic carcinoma
Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 9 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● #2 most common salivary gland tumor of lung, may arise from submucus bronchial glands
● Usually in large bronchi, may involve the trachea
● M:F 2:1
● Prolonged course, but overall prognosis is poor
● Frequent metastases to regional lymph nodes and lung parenchyma
● Radiation therapy (palliative)
● Large, centrally located, polypoid, intrabronchial mass, or may grow subepithelially along bronchi causing thickened bronchial wall
75 year old woman with 1 cm lung lesion
● Cylindromatous, tubular, and solid patterns of microcystic spaces containing mucin, surrounded by small tumor cells
● Defining features are pseudocysts (rounded extracellular space containing basal lamina), intercellular spaces, basal lamina, and true glandular lumens (Hum Pathol 1982;13:916)
14 year old girl with 11 cm lung mass
75 year old woman with 1 cm lung lesion: H&E, TTF1
● Basaloid squamous cell carcinoma: may have adenoid cystic carcinoma-like pattern of microcystic spaces containing mucin, surrounded by small tumor cells
● Epithelial-myoepithelial carcinoma
● Metastatic disease
End of Lung tumor > Other carcinoma > Adenoid cystic carcinoma
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