Lung tumor
Other carcinoma
Lymphoepithelioma-like carcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 27 December 2016, last major update September 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: lymphoepithelioma-like carcinoma lung
Cite this page: Lymphoepithelioma-like carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumorLEL.html. Accessed April 24th, 2017.
Definition / General
  • Rare tumor in lung, more commonly in Asians
  • In Asians, usually women, non-smokers, with EBV+ tumors (Am J Surg Pathol 2002;26:715)
  • In Caucasians, usually EBV-
  • Tumor size may correlate with EBV serology titer
  • May have better prognosis than other non-small cell carcinomas of lung (Cancer 2012;118:4748)
Case Reports
Gross Description
  • Well circumscribed nodules
Micro Description
  • Syncytial growth of epithelial cells with large vesicular nuclei, prominent eosinophilic nucleoli, accompanied by marked CD8+ lymphocytic infiltration
  • Predominantly pushing borders, permeative interface with adjacent lung
  • Occasional amyloid deposition
Micro Images

Images hosted on other servers:

Various images

Positive Stains
  • EBV, BCL2; variable EBER-1, LMP; patchy keratin
Negative Stains
Differential Diagnosis