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Lung tumor

Other Carcinoma

Lymphoepithelioma-like carcinoma


Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 12 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Rare tumor in lung, more commonly in Asians
● In Asians, usually women, non-smokers, with EBV+ tumors (Am J Surg Pathol 2002;26:715)
● In Caucasians, usually EBV-
● Tumor size may correlate with EBV serology titer
● May have better prognosis than other nonsmall cell carcinomas of lung (Cancer 2012;118:4748)

Case reports
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● 25 year old Italian man with EBV+ tumor (Hum Pathol 2003;34:623 )

Gross description
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● Well circumscribed nodules

Micro description
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● Syncytial growth of epithelial cells with large vesicular nuclei, prominent eosinophilic nucleoli, accompanied by marked CD8+ lymphocytic infiltration
● Predominantly pushing borders, permeative interface with adjacent lung
● Occasional amyloid deposition

Micro images
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Various images

Positive stains
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● EBV, BCL2; variable EBER-1, LMP; patchy keratin

Negative stains
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● CD45/LCA (in tumor cells)
● Microsatellite instability is uncommon (Am J Clin Pathol 2007;127:282)

Differential diagnosis
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Inflammatory pseudotumor
● Lymphoma
● Metastatic nasopharyngeal carcinoma

End of Lung tumor > Other carcinoma > Lymphoepithelioma-like carcinoma


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