Lung tumor - Lymphoepithelioma-like carcinoma

Home Chapter Home Jobs Conferences Fellowships Books

Lung tumor

Other Carcinoma

Lymphoepithelioma-like carcinoma

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 12 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Rare tumor in lung, more commonly in Asians
● In Asians, usually women, non-smokers, with EBV+ tumors (Am J Surg Pathol 2002;26:715)
● In Caucasians, usually EBV-
● Tumor size may correlate with EBV serology titer
● May have better prognosis than other nonsmall cell carcinomas of lung (Cancer 2012;118:4748)

Case reports
=========================================================================

● 25 year old Italian man with EBV+ tumor (Hum Pathol 2003;34:623 )

Gross description
=========================================================================

● Well circumscribed nodules

Micro description
=========================================================================

● Syncytial growth of epithelial cells with large vesicular nuclei, prominent eosinophilic nucleoli, accompanied by marked CD8+ lymphocytic infiltration
● Predominantly pushing borders, permeative interface with adjacent lung
● Occasional amyloid deposition

Micro images
=========================================================================

Various images

Positive stains
=========================================================================

● EBV, BCL2; variable EBER-1, LMP; patchy keratin

Negative stains
=========================================================================

● CD45/LCA (in tumor cells)
● Microsatellite instability is uncommon (Am J Clin Pathol 2007;127:282)

Differential diagnosis
=========================================================================

● Inflammatory pseudotumor
● Lymphoma
● Metastatic nasopharyngeal carcinoma

End of Lung tumor > Other carcinoma > Lymphoepithelioma-like carcinoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).