Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 10 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Substantial amounts of squamous and glandular differentiation (at least 5-10% each component of entire tumor)
● Donít diagnose if one component is clearly minor
● Uncommon; <10% of lung carcinomas
● 90% peripheral, often associated with scars
● Metastases may have different histology
● Poorer prognosis than either component alone
● TTF1 in adenocarcinoma component and p63 in squamous component (Pathol Int 2011;61:717)
With KRas and EGFR mutations
End of Lung tumor > Other carcinoma > Adenosquamous carcinoma
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