Lung tumor
Other malignancies

Author: Deepali Jain, M.D. (see Authors page)

Revised: 3 January 2017, last major update September 2012

Copyright: (c) 2003-2017,, Inc.

PubMed Search: pulmonary angiosarcoma
Cite this page: Angiosarcoma. website. Accessed October 15th, 2018.
Definition / general
  • Presents as mass or diffuse pulmonary infiltrates, usually in adult men (Ann Diagn Pathol 2010;14:296)
  • Almost all cases in lung represent metastatic disease
Case reports
Gross description
  • Diffusely hemorrhagic lungs with multiple dark red nodules
  • Involves interlobar septa and bronchovascular bundles
  • Grows along lymphatics or venous routes
Gross images

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Metastatic tumor at autopsy has multiple cystic nodules

Microscopic (histologic) images

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Primary angiosarcoma of lung shows (left to right): interanastomosing vascular spaces, tumor cells with atypia and hobnailing that dissect vascular spaces, solid sheets of epithelioid cells, primitive vessel formation

Primary epithelioid (left) and metastatic (right) disease

Differential diagnosis
  • Metastatic angiosarcoma