Lung tumor
Other malignancies
Angiosarcoma



Topic Completed: 1 September 2012

Revised: 31 January 2019, last major update September 2012

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PubMed Search: pulmonary angiosarcoma

Deepali Jain, M.D.
Page views in 2018: 446
Page views in 2019 to date: 385
Cite this page: Jain D. Angiosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumorangiosarcoma.html. Accessed October 22nd, 2019.
Definition / general
  • Presents as mass or diffuse pulmonary infiltrates, usually in adult men (Ann Diagn Pathol 2010;14:296)
  • Almost all cases in lung represent metastatic disease
Case reports
Gross description
  • Diffusely hemorrhagic lungs with multiple dark red nodules
  • Involves interlobar septa and bronchovascular bundles
  • Grows along lymphatics or venous routes
Gross images

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Metastatic tumor at autopsy has multiple cystic nodules

Microscopic (histologic) images

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Primary angiosarcoma of lung shows (left to right): interanastomosing vascular spaces, tumor cells with atypia and hobnailing that dissect vascular spaces, solid sheets of epithelioid cells, primitive vessel formation


Primary epithelioid (left) and metastatic (right) disease

Differential diagnosis
  • Metastatic angiosarcoma
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