Dysplasia / carcinoma in situ
Bronchioalveolar atypical adenomatous hyperplasia
Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 8 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● WHO: adenomatous lesion no more than 0.5 cm in diameter
● Also called adenoma, well differentiated bronchioalveolar carcinoma of Clara cell type / type II pneumocyte type
● Associated with coexisting bronchioloalveolar carcinoma and papillary adenocarcinoma
● May be precursor of bronchioloalveolar carcinoma of nonmucinous type (Hum Pathol 2002;33:697, Exp Ther Med 2012;4:1032, Am J Surg Pathol 1996;20:553); recommended to diagnose as such if malignant appearing but noninvasive
● Focal lesion
4 mm nodule
● Alveolar lining cells replaced by cuboidal cells with uniform, mildly to highly atypical nuclei, scanty cytoplasm, minimal mitotic figures
FNA shows sheet-like collection of monotonous pneumocytes with no overt features of malignancy (Pap)
End of Lung tumor > Dysplasia / carcinoma in situ > Bronchioalveolar atypical adenomatous hyperplasia
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