Lung tumor
Carcinoid and related tumors
Central carcinoid tumor

Author: Deepali Jain, M.D. (see Authors page)

Revised: 31 August 2018, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: central carcinoid tumor lung

Related Topics: carcinoid, peripheral
Cite this page: Jain, D. Central carcinoid tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumorcarcinoidcentral.html. Accessed September 24th, 2018.
Definition / general
  • Most common type, usually slow growing, associated with obstruction, infection, hemorrhage
  • Usually adults, but also most common lung tumor of children
  • 5% metastasize, usually to regional lymph nodes
  • Rarely distant osteoblastic metastases to bone
  • 10 year survival 70%
  • Cytology often negative since tumor is covered by mucosa
Radiology images

Images hosted on PathOut server:

Case of the Week #266

Case reports
Treatment
  • Surgical resection
Gross description
  • Solitary, intrabronchial polypoid mass that may infiltrate bronchial wall, covered by intact mucosa
  • Gray-yellow cut surface, cartilage may be present
Microscopic (histologic) description
  • Nests or cords of uniform, bland cells with central nuclei and moderate granular cytoplasm, prominent vasculature, stroma may be delicate fibrovascular, hyalinized or exhibit calcification
  • Angiolymphatic invasion common
  • Rarely mitotic figures, rosettes or papillary architecture, endocrine atypia, melanin granules
  • May have paraganglioma appearance with S100+ sustentacular cells
  • Sox10+ sustentacular cells observed in carcinoid tumours but not in high-grade NECs (Histopathology 2011;58:276)
  • May have oncocytic features (abundant granular eosinophilic cytoplasm with numerous mitochondria by EM, Hum Pathol 2011;42:578)
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #266:


AE1-AE3

Chromogranin

Synaptophysin

NSE

Positive stains
  • Keratin, serotonin, neuron-specific enolase, chromogranin A and B, synaptophysin, CD57/Leu7, pancreatic polypeptide, N-CAM
Negative stains
Molecular / cytogenetics description
  • 1/3 are aneuploid, which doesn’t appear to affect prognosis
Electron microscopy description
  • Dense core secretory granules that vary in shape and size
Differential diagnosis