Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 16 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Sputum or bronchial brushings are 80-90% sensitive for lung carcinoma if examine 5+ sputum samples
● Fine needle aspirate is superior to bronchoalveolar lavage for diagnosis of pathologic pathology (Mod Pathol 2002;15:1259)
● False positives: due to misidentification of macrophages or pneumocytes - includes bronchiectasis, fungal infections, infarct, lipoid pneumonia, post-radiation changes, viral pneumonia
● False negatives: often due to sampling (Diagn Cytopathol 2012;40:556); pleural fluid cytology is often falsely negative for small cell carcinoma
● Also useful for mutation analysis (Acta Cytol 2012;56:661)
Squamous cell carcinoma
End of Lung tumor > Other > Cytology
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