Lung tumor - Desmoplastic small round cell tumor

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Lung tumor

Other malignancies

Desmoplastic small round cell tumor

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 22 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

Case reports
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● 22 year old man (Arch Pathol Lab Med 2002;126:1226)

Micro description
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● Nests of small round tumor cells within a cellular and vascular collagenous stroma

Micro images
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H&E, stains

Positive stains
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● AE1/AE3, EMA, CAM5.2, vimentin, desmin, neuron-specific enolase, WT1

Negative stains
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● Thrombomodulin, calretinin

Electron microscopy description
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● Intracytoplasmic whorls of intermediate filaments

Electron microscopy images
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Cytoplasmic perinuclear aggregates of intermediate filaments

Molecular description
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● t(11;22)(p13;q12) [EWS-WT1 gene fusion]

Molecular images
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RT-PCR

End of Lung tumor > Other malignancies > Desmoplastic small round cell tumor

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