Lung tumor - Epithelial-myoepithelial carcinoma

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Lung tumor

Other Carcinoma

Epithelial-myoepithelial carcinoma

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 12 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Low grade malignancy that arises from submucosal bronchial glands, mimics similar salivary gland tumor
● Very rare, < 20 cases reported through 2009
● Ages 40-69 years
● Long interval to recurrence or metastasis

Case reports
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● 57 year old man with incidental endobronchial tumor (Case Report Pathol 2012;2012:319434)
● 73 year old man with bronchial tumor (Arch Pathol Lab Med 2003;127:e177)

Gross description
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● Intraluminal polypoid mass in bronchus; may invade pulmonary parenchyma

Gross images
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Incidental endobronchial mass

Micro description
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● Well circumscribed mass, pushing margin
● Biphasic proliferation of epithelial and myoepithelial cells with formation of bilayered ductlike structures
● Tumor consists of ductlike structures with inner epithelial cells and outer clear myoepithelial cells
● No myxoid/chondroid stroma, no perineural invasion (Hum Pathol 2009;40:366)

Micro images
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Various images

Incidental endobronchial mass

Positive stains
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● Epithelial cells: cytokeratin, EMA
● Myoepithelial cells: S100, muscle specific actin, weak keratin

Negative stains
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● Epithelial cells: S100, HMB45

Differential diagnosis
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● Acinic cell carcinoma
● Adenoid cystic carcinoma with a tubular pattern
● Clear cell (“sugar”) tumor
● Metastatic clear cell carcinoma
● Metastatic epithelial-myoepithelial carcinoma (usually parenchymal, not endobronchial)
● Mucoepidermoid carcinoma
● Myoepithelial carcinoma
● Myoepithelioma
● Pleomorphic adenoma
● Pneumocytic adenomyoepithelioma: has bronchial minor salivary gland origin; shows myoepithelial and pneumocytic differentiation (Am J Surg Pathol 2007;31:562)

End of Lung tumor > Other carcinoma > Epithelial-myoepithelial carcinoma

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