Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Lung tumor

Other Carcinoma

Giant cell carcinoma


Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 12 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Malignant epithelial neoplasm predominantly composed of giant, pleomorphic cells (WHO)
● First described in 1958 (Cancer 1958;11:369)
● <1% of all primary lung carcinomas

Case reports
=========================================================================

● 51 year old man with small intestinal metastases (World J Surg Oncol 2005 Jun 2;3:32)
● 56 year old man with hemoptysis (J Cancer Res Ther 2011;7:363)

Gross images
=========================================================================



8 x 7 cm tumor

Micro description
=========================================================================

● Neoplastic, highly pleomorphic giant cells, often in inflammatory stroma with emperipolesis (Arch Pathol Lab Med 2010;134:1645)
● Giant cells are multinucleated, may resemble syncytiotrophoblasts and produce human chorionic gonadotropin, but are usually fewer than in primary choriocarcinoma of lung (Histopathology 2000;36:17)
● No sarcomatoid component present

Micro images
=========================================================================



8 x 7 cm tumor


Diffuse proliferation of atypical, giant and bizarre cells


Emperipolesis

Positive stains
=========================================================================

● Calretinin (67%)

End of Lung tumor > Other carcinoma > Giant cell carcinoma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).