Lung tumor
Other carcinoma
Giant cell carcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 22 December 2016, last major update September 2012

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PubMed Search: giant cell carcinoma lung
Cite this page: Giant cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumorgiantcellcarcinoma.html. Accessed August 23rd, 2017.
Definition / general
  • Malignant epithelial neoplasm predominantly composed of giant, pleomorphic cells (PubCan)
  • First described in 1958 (Cancer 1958;11:369)
  • < 1% of all primary lung carcinomas
Case reports
Gross images

Images hosted on other servers:

8 x 7 cm tumor

Microscopic (histologic) description
  • Neoplastic, highly pleomorphic giant cells, often in inflammatory stroma with emperipolesis (Arch Pathol Lab Med 2010;134:1645)
  • Giant cells are multinucleated, may resemble syncytiotrophoblasts and produce human chorionic gonadotropin, but are usually fewer than in primary choriocarcinoma of lung (Histopathology 2000;36:17)
  • No sarcomatoid component present
Microscopic (histologic) images

Images hosted on other servers:

8 x 7 cm tumor

Diffuse proliferation of atypical, giant and bizarre cells

Positive stains
  • Calretinin (67%)