Giant cell carcinoma
Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 12 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Malignant epithelial neoplasm predominantly composed of giant, pleomorphic cells (WHO)
● First described in 1958 (Cancer 1958;11:369)
● <1% of all primary lung carcinomas
● 51 year old man with small intestinal metastases (World J Surg Oncol 2005 Jun 2;3:32)
● 56 year old man with hemoptysis (J Cancer Res Ther 2011;7:363)
8 x 7 cm tumor
● Neoplastic, highly pleomorphic giant cells, often in inflammatory stroma with emperipolesis (Arch Pathol Lab Med 2010;134:1645)
● Giant cells are multinucleated, may resemble syncytiotrophoblasts and produce human chorionic gonadotropin, but are usually fewer than in primary choriocarcinoma of lung (Histopathology 2000;36:17)
● No sarcomatoid component present
8 x 7 cm tumor
Diffuse proliferation of atypical, giant and bizarre cells
● Calretinin (67%)
End of Lung tumor > Other carcinoma > Giant cell carcinoma
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